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Bladder & Prostate

PollenAid contains a concentrated clinical formulation of essential phyto-nutrient combinations that promote healthy function of the prostate and bladder. Backed by over 40 years of clinical research, for efficacy and safety, the supplement has been shown to improve urinary control, flow rate and clearance via the action on smooth muscle, reduce the size and congestion of prostate cells, improve metabolism and prohibit the production of DHT (dihydrotestosterone).
    

As we mature, various functional, and form and structure changes take place in and around the bladder.

Weakened Detrusor Muscle which results in wanting to go to the toilet more often, reduced flow/stop/start and the inability to completely empty the bladder. For women who have had a hysterectomy, this can result in "dribbling" after they stand up again which is obviously distessing.

Please note: high consumtion of diuretics such as tea and coffee and alcohol can make increased urination more common for obvious reasons.

Bladder outlet obstruction reduces the flow of urine when you go to the toilet. In extreme conditions, this blockage can prevent all voiding and is extremely serious.

bullet  What is the Prostate?

The prostate is a gland of the male reproductive system about the size and shape of a walnut. its main role is to push fluid into the urethra as sperm passes through. Enlargement of the prostate doesn't usually cause problems until late in life, but affects more than 50% of men in their sixties and more than 80% in their seventies and eighties.

The most common signs of a prostate problem include:

  • Weak flow
  • Intermittency – a flow which stops and starts
  • Hesitancy – having to wait before you start to go
  • Frequency – having to urinate more often than previously
  • Urgency – finding it difficult to postpone urination
  • Nocturia – having to get up one or more times at night to urinate

If you feel that you are getting any of these signs, please contact your GP or Consultant.

Pollen Aid contains a concentrated clinical formulation of Rye Pollen, an essential phyto-nutrient combination that has undergone independent studies to demonstrate the promotion of healthy function of the prostate and bladder. Backed by over 40 years of clinical research, for efficacy and safety, the supplement has been shown to improve urinary control, flow rate and clearance via the action on smooth muscle, reduce the size and congestion of prostate cells, improve metabolism and prohibit the production of DHT (dihydrotestosterone). 

bullet  Background Scientific & Biomedical Information for PollenAid

bullet  Prostatic congestion: The cause of voiding difficulties.

Inflammation of the prostate results in edema of the interstitial stromal tissue surrounding the acini and ducts of the gland leading to congestion and poor secretory drainage. The swelling of the prostate gland that ensues from this pathological process, which can affect the normal as well as the hyperplasic gland, causes difficulty with voiding, dysuria, frequency and nocturia. It accounts for the discomfort and pain of chronic non-bacterial prostatitis and prostatodynia.

bullet  Inhibition of the Arachidonic Acid Cascade

The anti-congestive action of PollenAid is based on the inhibition of the prostaglandin and leukotriene biosynthesis, the activities of both the 5-lipoxygenase and cyclo-oxygenase enzymes are markedly reduced and the arachidonic acid.

Prostate Support

The inhibition of the arachidonic acid cascade by Graminaceae pollen extract prevents intraprostatic tissue edema and fibrosis, and leads to a significant reduction in clinical symptoms (Literature: 1-6, 8).

bullet  Inhibition of prostaglandin and leukotriene biosynthesis

Inhibition of prostaglandin & leukotriene biosynthesis

bullet  Chart: Pollen Aid inhibits the cyclo-oxygenase and the 5-lipoxygenase and thus reduces the biosynthesis of prostaglandins and leukotrienes and arachidonic acid.

Enlargement and congestion of the prostate gland are the principal factors responsible for the obstructive symptoms in patients with BPH. Histological examination of the gland shows that interstitial edema with an inflammatory cell infiltrate is a major contributory factor. The anti-inflammatory action of fx prostate & bladder is therefore, a pharmacologically effective therapeutic principle.

bullet  Anti-congestive effect of Pollen Aid

The anti-congestive effect of Pollen Aid leads to a marked reduction in prostate volume in stage II and III of BPH (Vahlensieck).

bullet  Shrinkage of prostate.

Prostate size before fx prostate & bladder        Prostate size after fx prostate & bladder

bullet  Images: Transrectal ultra sonography of the prostate before and after 6 months treatment with Pollen Aidt. Marked reduction of the circumference, transverse and a-p diameter of the prostate (Literature: 4).

bullet  Voiding Difficulties in BPH

In BPH patients the decongestive effect of PollenAid leads to a lasting improvement of voiding difficulties. High response rates are also obtained in one of the main symptoms of BPH, namely nocturia.

Residual urine decreases, on average, by 47%; the superiority of Pollen Aid in comparison with placebo is significant.

bullet  Significant superiority of Pollen Aid

 

 

Parameter Active Drug Placebo
     
Clinical symptom    
  Seeing significant improvement (%)  
Nocturia 66.7 37.2
Frequency 61.9 37.0
  Becoming symptom-free (%)  
Frequency 45.2 15.2
Sensation of incomplete emptying 38.2 3.8
     
Urodynamics     
     
Residual urine Volume  
-- Before therapy (ml: x ± s) 54.5 ± 24.9 51.9 ± 32.0
-- After therapy (ml: x ± s) 28.9 ± 19.7 44.9 ± 28.6
-- Reduction (%) 47.0 13.5
     
Global assessment of overall outcome by Physician Very Good 37.2% 11.4%


bullet  Table: Results of the double blind study: Significant differences is favor of Pollen Aid clinical symptomatology and urodynamics (Literature: 2).

bullet  Urodynamics in BPH

The anti-congestive effect of the Graminaceae pollen extract leads to marked improvement of the difficulties of micturition. The residual urine volume decreases significantly (Literature: 1 2, 4). The therapeutic evaluation confirms the superiority of the Graminaceae pollen therapy (Literature: 1).

bullet  Reduction of the residual urine volume.

fx prostate reducing urine volume

bullet  Graph: Course of the residual urine volume (ml) in BHP stage Ill. Significantly different and con ti9uous decrease in the residual urine volume under treatment with pollen extract (Literature: 1).

bullet  Positive evaluation of therapeutic response.

fx prostate improving therapeutic response

bullet  Graph: Significantly better evaluation of therapeutic and patient in the pollen extract group (Literature: 1) response by clinician.

bullet  Literature:

Graminaceae Pollen Extract Studies:


1. Becker H Ebeling L, Konservative Therapie der benignen Prostata Hyperplasie (BPH). Urologe B28 301-3061988
2. Becker H, Ebeling L, Phytotherapre der BPH. Egebnisse einei kontrotierten Verlaufsstudie Urologe B31, 113-116 1991
3. Buck AC et al. Treatment of chronic prostatitis and prostatodynia with pollen-extract British Journal of Urology 64. 496-499, 1989
4. Buck AC et al.. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract A double- blind, placebo-controlled study. British Journal of Urology. 66, 398-404,1990
5. Ebeling L The therapeutic results of defined pollen extract in patients with chronic prostatitis or BPH accompanied by chronic prostatitis. In Schmiedt E, Aiken JE. Bauer HW (eds) Therapy of Prostatitis. Zuckschwerdt Verlag MOnchen S 154- 1601986
6. Leander G. A preliminary investigation on the therapeutic effect of Pollen Extract in chronic prostatovesiculitis Svenska Ldkartidningen 59(45), 3296,1962
7. Loschen G, Ebeling L, Hemmung der Arachidons,;—ure-Kaskade durch einen Extrakt aus Roggenpollen Arzneimittelfor schung41 (1), 162 167 1991
8. Rugendorff E et al. Results of Treatment with Pollen Extract in Prostatodynia and Chronic Prostatitis British Journal of Urol ogy 1992 (in press)

bullet  Further Literature:

9. Barbalias GA et al . Prostatodynia Clinical and urodynamic characteristics Journal of Urology 130 13i 514-517 1083
10. Barbalias GA, Prostatodynia or painful male urethral syndrome? Urology 36 (2), 146 153, 1990
11. Boyarsky S et al , A new look at bladder neck obstruction by the Food and Drug Administration regulators guide lines for investigation of benign prostatic hypertrophy. Transactions of the American Association of Genito-Urinary Surgeons 68 29 32. 1977
12. Di Tranpani D et al . Chronic prostatitis and prostatodynia Ultrasonographic alterations of the prostate, bladder neck seminal vesicles and periprostatic venous plexus European Urology 15 (3-4) 230 234,1988
13. Greenberg RN et al Chronic prostatitis Comments on infectious etiologies and antimicrobial treatment Prostate 6 141 445- 448. 1985
14. Habib F et al. Androgen metabolism in the epithelial and stromal components of the human hyperplastic prostate Journal of Endocrinology 91, 23-32. 1981
15. Hinman F jr (ed). Benign prostatic hypertrophy Springer Verlag New York Heidelberg Berlin 1983
16. Ireton RC, Berger RE, Prostatitis and epididymitis Urologic Clinics of North America 11 11) 83-94 1984
17. Krieger JN et al Diagnostic considerations and interpretation of microbiological findings of evaluation of chronic prostatitis a Journal of Clinical Microbiology 27 110). 2240 2244, 1989
18. Lancet. Medical treatment of benign prostatic hyperplasia. Lancet 1 1083-1084 1988
19. Orland SM et al . Prostatitis. prostatosis. and prostatodynia. Urology 25 (5). 439-459 1985
20. Riedasch Get al Antibody-coated bacteria in ejaculate in bacterial prostatitis Urology 23 (3) 252-255 1984
21. Shortliffe LM Prostatitis Still a diagnostic and therapeutic dilemma Western Journal of Medicine 139 (41 542-544 198
22. Thin RN Simmons PD. Chronic bacterial and non-bacterial prostatitis British Journal of Urology 55 15) 513-518 1983
23. Vahlensieck W Dworak 0. Abgrenzuog der rezidivierenden Prostatakongestion von dec cbronrschen Prostatitis (Deliminatiori between recurrent congestion of the prostate and chronic prostatitis Helvetica Chirurgica Acta 555 (3). 293 296 1988
24. Vahlensieck W Rutishauser G (eCs). Benign prostme diseases. G Thieme-Verlag Stuttgart. New-York. 1992
25. Weidner W et al . Chlarnydia trachomatis in abacterial’ prostatitis Microbiologica . cytological and serological studies Urologia Internatonalis 28)3). 146-149.1983
26. Weidner W. Moderne Prostatitisdiagnostik Klinische und experimentelle Urologie 7 1-211 1984
27. Wilson JD The pathogenesis of benign prostatic hyperplasia American journal of Medicine 68 745-756.1980 

These phyto-nutrient combinations can help support and maintain a healthy bladder and prostate, as evidenced by results from a large number of clinical trials.
PollenAid provides over 130 essential micro nutrients to the body, many of which are missing in the average daily diet; these include Essential and Non-Essential Amino Acids, B-Complex Vitamins, Choline, Inositol, Enzymes, and Flavonoids.  

bullet  Why use PollenAid?

  •  Backed by over 40 years of clinical research, for efficacy and safety, flower pollen extract has been shown to improve urinary control, flow rate and clearance via the action on smooth muscle.  
  • When included in your diet, it works quickly, often within 28 days.
  • PollenAid contains extracts from Rye Grass pollen grown under organic conditions in the USA; produced to the highest quality and tested to U.S. Pharmacopeia Standard, no solvents are used during the extraction process and all allergens are destroyed, making it safe for use by hay fever sufferers. It is both Kosher and Hallal approved.
  • Flower Pollen Extract reduces the size and congestion of the prostate cells while improving urinary flow rate and clearance via action on the smooth muscle of the bladder, benefits the metabolism and reduces the production of DHT (dihydrotestosterone)

bullet  Why supplement a conventional diet with a pollen extract?

The health of the body depends not just on the basic foods ingredients (proteins, fats, carbohydrates, minerals and vitamins) but also on minute quantities of biologically necessary elements, many of which can be sourced from pollen.

Pollen is the male seed of flowers which enables flowering plants to reproduce. It is produced in the upper part, or anthers, of the flower. Pollen grains contain all the substances that are necessary to create new life within the world of plants. PollenAid is a concentrate of these vital substances in a form convenient for human consumption.

bullet  References:

A Critical Review of Cernitin™ for Symptomatic Relief Of Lower Urinary Tract Symptoms (LUTS) in Men.
A Critical Review of Graminex Flower pollen extract for Symptomatic Relief Of Lower Urinary Tract Symptoms (LUTS) in Men.
Effects of Cernitin™ pollen extract (CN-009) on the isolated bladder smooth muscles and the intravesical pressure.

 

 

 

 

PollenAid provides over 230 essential micro nutrients to the body, many of which are missing in the average daily diet; these include Essential and Non-Essential Amino Acids, B-Complex Vitamins, Choline, Inositol, Enzymes, and Flavonoids.

bullet  Dietary Essential Amino Acids and Physiological Essential Amino Acids:

bullet  Dietary Essential:
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine

bullet  Physiologically Essential:
Alanine
Alpha-amino butyric acid
Arginine
Asparagine
Aspartic Acid
Cysteine
Cystine
Glutamic Acid
Glutamine
Glycine
Hydroxyproline
Proline
Serine
Tyrosine

bullet  Enzymes:

bullet  Class: Oxidoreductases
Alcohol dehydrogenase
D-Arabinitol dehydrogenase
Inositol aehyarogenase
UDP-Glucose dyhydrogenase
Lactate dehydrogenase
Malate dehydrogenase
Isocitrate dehydrogenase (NADP)
Phosphogluconate dehydrogenase
Glucose dehydrogenase
Glucose-6-phosphate dehydrogenase
Trosephosphate dehydrogenase
Malonate semialdehyde dehydrogenase
Succinate dehydrogenase
Glutamate dehydrogenase (NADP)
L-Amino-acid oxidase
Monoamine oxidase
Lpoamide dehydrogenase
Cytochrome oxidase
o-Diphenol oxidase, tyrosinose
Ascorbate Oxidase
Fatty acid peroxidose
Catalose
Peroxidose
Meso-inositol oxygenase

bullet  Class: Transferases
Asparate carbamoyltransferase
alphaGlucan-phosphorylase, P-enzyme
Maltose 4-glucosyltransferase, amylomaltase
UDP-Glucose-beta-glucan glucosyltransferase
Trehalosephosphate-UDP glucosyltransferase
alphaGluecanbranching glycosyltransferase
UDP-Galactose-glucose galactosyltransferase
Aspartate aminotransferase
Alanine aminotransferase
Glycine aminotransferase
Hexokinase
Glucokinase
Xylulokinase
Phosphoribulokinase
Glucuronokinase
Nucleosidediphosphate kinase
Phosphoglucomutase
DNA Nucleotidyltransferase
UDP-Glucose pyrophosphorylase
ADP-Glucose pyrophosphorylase
Ribonuclease (R Nase)

bullet  Class: Hydrolases
Carboxylesterase (B-esterase)
Arylesterase (A-esterase)
Lipase
Cultinase
Pectinesterase
Alkaline phosphatase
Acid phosphatose
Phytase
Trehalosephosphatase
Phosphodiesterase
Deoxyribonuclease (D Nase)Arysulphatase
alpha-Amylase
beta-Amylase
Cellulase
Laminaranase (Callase)
Polygalacturonase (Pectinase)
alpha-Glucosidase
beta-Glucosidase
beta-Glucosidase
alpha-Mannosidase
beta-Fructofuranosidase, Invertase
 

    

Trenalase
beta-N-Acetyglucosaminidase
Oligo-1, 3-glucosidase
Leucine aminopeptiadase
Aminopeptidase
Pepsin, Protease
Trypsin
Aminoacylase
Inorganic phrophosphatase
ATPase
ATPase

bullet  Class: Lyases
Pyruvic decarboxylase
Oxaloacetat decarboxylase
Mesoxalic decarboxylase
Glutamic aecarboxylase
Phosphopyruvate carbonxylase
Phosphopyruvate carbonxylase
Ribulosediphosphate carboxylase
carboxydismutase
Ketose-1-phosphate aldolose
Fructosediphosphate aldolase
Citrate synthase (synthetase)
Phenylaranine ammonia-lyase

bullet  Class: Isomerases
UDP-Glucose epimerase
Arabinose isomerase
Xylose isomerase
Ribosephosphate isomerase
Glucosephosphate isomerase

bullet  Class: Ligases and Others
Carboxylases
Folic acid conjugase


D-glucose-6-P- cycloaldolase (NAD+)

bullet  Different Classes of Lipids in Flower Pollen:
Polar lipids: The major fractions of the polar lipids in flower pollen are lecithin, lysolecithin, phosphoinositol and phosphatidylcholine

bullet  Neutral lipids:
Monoglycerides
Diglycerides
Triglycerides
Free fatty acids
Sterols
Hydrocarbons

bullet  Fatty Acid Profile:
Number of C-atoms and double bonds:
Caprylic acid (C-8)
Capric (C-10)
Lauric (C-12)
Myristic (C-14)
Myristoleic (C-14) one double bond
Pentadecanoic (C-15)
Pentadecenoic (C-15) one double bond
Palmitic (C-16)
Palmitoleic (C-16) one double bond
Heptadecanoic (C-17)
Heptadecanoic (C-17) one double bond
Stearic (C-18)
Oleic (C-18) one double bond
Linoleic (C-18) two double bonds
Linolenic (C-18) three double bonds
Arachidic (C-20)
Eicosenoic (C-20) one double bond
Eicosadienoic (C-20) two double bonds
Eicosatrienoic (C-20) three double bonds
Arachidonic (C-20) four double bonds

bullet  Prostaglandins: A group of hormone-like compounds derived from linoleic and arachidonic acids that influence innumerable body processes.

bullet  Phytosterols:
Fucosterol 
Beta-sitosterol
Stigmasterol
Campesterol
Estrone

bullet  Long Chain Hydrocarbons:
n-tricosane (C23)
n-pentacosane (C25)
n-heptacosane (C27)
n-nonacosane (C29)
myo-inositol
Pintol
Sequitol

bullet  Strepotolysin Inhibitory Factor: From Graminex ™ extract it was possible to isolate a streptolysin-inhibiting factor. The basic principle is a heat resistant factor (SIF) with a molecular weight of 850. In vitro, it causes irreversible inhibition of the streptococcus toxins.

bullet  Low Molecular Weight Sugars and Related Compounds:
Fructose
Mannose
Galactose
Arabinose

    

Ribose
Fucose
Hexasamine
Rhamnose
Maltotetratose
Maltrose
Myo-inosistol
Sequoyitol
Maltotriose
Glucose
Xylose
Xyitole
Xylogaracturonan
Glucoronolactone
Raffinose
Stachyose
Sucrose
Callose
Pinitol

bullet  Flavinoids:
Quercetin
Dihydroxquercetin
Naringenin
P-coumaric Acid
Apigenin
Sorhamnetin
Myricetin
Isorhemnetin
Kaempferol
Dihydrokaempferol
Luteolin

bullet  Growth Regulators:
Auxins
Brassins
Gibberelins
Kinins

bullet  Vitamins**:
Provitamin A (carotenoids)
B1 Thiamine
B2 Riboflavin
Niacin
B6 Pyridoxine
Pantothenic Acid
Biotin
B 12 (Cyanocobalamirn)
Folic Acid
Choline
Inositol
Vitamin C
Vitamin D
Vitamin E
Vitamin K
Ratin

bullet  Carotenoids:
Alpha-carotene
Beta-carotene
Xanthophyll
Zeaxanthin
Lycopene
Crocetin
Cryptoxanthin

bullet  Minerals**:
Calcium
Phosphorus
Potassium
Sulphur
Sodium
Clorine
Magnesium
Iron
Manganese
Copper
Iodine
Zinc
Silicon
Chromium
Molybdenum
Boron
Titanium

bullet  Others:
Chlorophylt
Hypoxalthine
Tarpenes
Hexodecanal
Guanine
Indoles
Polyphenols
Phenolic Acids (Catechin, Epicetoohln, Gallio)
Xanthine
Phenolic Acids
Amines
Vernine
Gluthothlone
Superoxide Eismutase (SOD)
Pentosane
Nucleic Acids
Nuclein
Nucleosides
Pentosans
Ferulic Acid
Adenosine Triphoephate (ATP)
Ellagic Acid

** There are established RDAs for many vitamins and minerals. PollenAid contains trace amounts of these ingredients.